I've been using this serum (with the other Issada cleansers, moisturisers and makeup) for a few months now, and the difference it's made is amazing. I posted a photo the other day, and people asked me what my secret was as, apparently, I don't age! I told them it was my Issada products. I have honestly noticed a big difference in my fine lines and wrinkles and I'm now using these products on my partner whose deeper wrinkles are slowly plumping out.